Indications and Usage
INFLUVAC Influenza vaccine (surface antigen, inactivated) containing the purified haemagglutinin and neuraminidase antigens prepared from the A and B influenza virus strains recommended by WHO. Prophylaxis of influenza in adults and children from 6 months of age.
Dosage and Administration
For intramuscular injection only.
- 6 months to >3 years old (not previously vaccinated with influenza vaccine) – Two doses (0.25 ml/0.5 ml each) at least 4 weeks apart
- 6 months to >3 years old (vaccinated with influenza vaccine in a previous season) – One dose (0.5 ml each)
- 3 years old up – One dose (0.5 ml)
Dosage Forms and Strengths
Suspension for injection supplied in 0.5-mL single-dose prefilled syringes.
- Hypersensitivity to active ingredients or excipients (see SPC) and to any components that may be present as traces such as eggs(ovalbumin, chicken proteins), formaldehyde, cetyltrimethylammonium bromide, polysorbate 80 or gentamicin.
- Postpone immunisation in patients with febrile illness or acute infection.
Warnings and Precaution
- Appropriate medical treatment and supervision should be available in case of a rare anaphylactic event. Not to be administered intravascularly. Antibody response may be insufficient in immunosuppressed patients or those receiving immunosuppressive treatment. Interference with serological testing.
- Drug Interactions: Influvac or Imuvac may be given at the same time as other vaccines, but separate limbs should be used. Following influenza vaccination, false positive results using the ELISA method to detect HIV1, Hepatitis C and HTLV1 antibodies have been seen. Immunological response may be reduced in patients on immunosuppressant treatment.
- Headache, sweating, myalgia, arthralgia, fever, malaise, shivering, fatigue.
- Local reactions: redness, swelling, pain, ecchymosis, induration.
- Transient thrombocytopenia, transient lymphadenopathy, allergic reactions in rare cases leading to shock, angioedema.
- Neuralgia, paraesthesia, febrile convulsions, neurological disorders such as encephalomyelitis, neuritis and Guillain Barré syndrome.
- Vasculitis associated in rare cases with transient renal involvement.
- Generalised skin reactions e.g. pruritus, urticaria, rash.